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KMID : 0379520060220040417
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한국독성학회지
2006 Volume.22 No. 4 p.417 ~ p.422
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Incidence of Micronuclei in Lymphocytes of Cattle in the High Background Radiation Area
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Lee Hae-June
Kang Chang-Mo
Kim Se-Ra
Moon Chang-Jong
Kim Jong-Choon
Kim Il-Hwa
Jo Sung-Kee
Jang Jong-Sik
Kim Seong-Ho
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Abstract
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Cytogenetic and hematological analysis was performed in peripheral blood obtained from cattle bred in the high background radiation areas (HBRA, Goesan-gun, Cheongwon-gun, Boeun-gun) and a control area. The frequencies of gamma-ray induced micronuclei (MN) in the cytokinesis-blocked (CB) lymphocytes at several doses were measured in 3 cattle. An estimated dose of radiation was calculated by a best fitting linear-quadratic model based on the radiation-induced MN formation from the bovine lymphocytes exposed in vitro to radiation over the range from 0 mGy to 1,969 mGy. The measurements performed after irradiation showed dose-related increases in the MN frequency in each donors. The results were analyzed using a linear-quadratic model with a line of best fit of y=(0.0583{pm}0.0137)D+(0.0366{pm}0.0081)D^2+(0.0093{pm}0.0015) (y=number of MN/CB cells and D=irradiation dose in Gy). MN rates per 1,000 CB lymphocytes of cattle from the Goesan-gun, Cheongwon-gun, Boeun-gun and the control area were 6.50{pm}2.72,;9.00{pm}4.50,;10.89{pm}4.23;and;9.60{pm}4.70, respectively. The MN frequencies of CB lymphocytes from cattle bred in 4 areas mean that the values are within the background variation in this experiment. The MN frequencies and hematological values were similar regardless of whether the cattle were bred in the HBRA or the control area.
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KEYWORD
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Micronuclei, Cattle, Lymphocyte, High background radiation area
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